twig variables

Use variable from settings.php in Twig Drupal 9 || Drupal 10

MY_THEME.theme

use Drupal\Core\Site\Settings;
use Twig\TwigFilter;
use Twig\TwigFunction;
use Twig\Extension\AbstractExtension;
/**
* Implements hook_twig_tweak_functions_alter().
*/
function bootstrap_for_drupal_twig_tweak_functions_alter(array &$functions): void {
 $functions[] = new TwigFunction('drupal_settings', [Settings::class, 'get']);
}

Front-end:

{{ drupal_settings('file_public_path') }}